Exposure of Peromyscus leucopus to lead and cadmium in the Southeast Missouri Lead Mining District

The exposure of white-footed mice (Peromyscus leucopus) to lead and cadmium and the potential associated toxic effects were examined at three sites contaminated with lead in the Southeast Missouri Lead Mining District and at a reference site. Mice from the contaminated sites showed evidence of oxidative stress and red-blood cell δ-aminolevulinic acid dehydratase (ALAD) activity was depressed by an average of 68% at the most contaminated site. However, histological examinations of the liver and kidney, cytologic examination of blood smears and biomarkers of lipid peroxidation and DNA damage failed to show evidence of toxic effects from lead. The biomagnification ratio of cadmium (hepatic concentration/ soil concentration) at a site [...]